Download PDF by Marco Baggiolini (auth.), I. J. D. Lindley, J. Westwick, S.: The Chemokines: Biology of the Inflammatory Peptide

Download PDF by Marco Baggiolini (auth.), I. J. D. Lindley, J. Westwick, S.: The Chemokines: Biology of the Inflammatory Peptide

By Marco Baggiolini (auth.), I. J. D. Lindley, J. Westwick, S. Kunkel (eds.)

The first symposium during this sequence was once held on the Royal collage of Surgeons of britain in December 1988 and used to be entitled "Novel Neutrophil Stimulating Peptides". That symposium effectively introduced jointly the vast majority of laboratories operating within the quarter of interleukin-8 and similar peptides; see Immunology this day 10: 146-147 (1989). the second one overseas Symposium on Chemotactic Cytokines used to be held on the comparable venue in June 1990, and a much-increased attendance mirrored the accelerating speed of labor within the zone of those chemotactic cytokines. The court cases of that assembly have been released in Advances in Experimental drugs and Biology, vol. 305 (1991). The quick advances made within the box of chemotactic cytokines during the last 18 months necessitated a 3rd Symposium during this sequence to collate and position in point of view an explosion of recent facts. The 3rd foreign Symposium on Chemotactic Cytokines was once held among August 31 and September 1, 1992 in Baden-bei-Wien, Austria. in spite of the fact that, the shortcoming of a transparent nomenclature procedure was once growing a few confusion within the region, particularly as new components stay chanced on and labeled as kinfolk. long ago, those inflammatory mediators have been put arbitrarily less than the vast heading of "intercrines" or "chemotactic cytokines" with out transparent type guidance to persist with. This nomenclature factor was once addressed on the Symposium, the place investigators within the box have been invited to arrive a consensus relating to a collective identify for those mediators. The ensuing selection was once to spot the foremost kinfolk as chemokines, to switch all prior terms.

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And EJ. Leonard. 1990. Identification of high affinity receptors for human monocyte chemoattractant protein-Ion human monocytes. J. Immuno!. 145: 292-297. , 1. 1. e. I. Wood. 1991. Structure and functional expression of a human interleukin-8 receptor. Science. 253: 1278-1280. M. L. Tiffany. 1991. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science. 253: 1280-1283. Neote, K, D. Y. Mak, R. 1. Schall. 1993. Molecular cloning and expression, and signalling characteristics of a C-C chemokine receptor.

L. Kunkel. 1989. Neutrophil-activating peptide-I/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84: 1045-1049. Matsushima, K. and U. Oppenheim. 1989. Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF. Cytokine. I: 2-12. , K Matsushima, S. A. Robinson, E. Appella, JJ. Oppenheim, and EJ. Leonard. 1987. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequene similarity to other host defence cytokines.

4). This indicates that HuMIP-la is desensitizing the cell to all other chemokines tested. By contrast, if MCP-l is added first, followed by HuMIP-l~, then RANTES, then HuMIP-la, four Ca++ fluxes are clearly induced (Fig. 4). In fact, depending solely on the order in which the same ligands are added to the cells, all combinations of 1, 2, 3 and 4 fluxes are observed. \-------- M/IlIAIa oJR o 60 120 180 240 0 60 120 180 240 TIme (seconds) Figure 4. Representation of intracellular CaM fluxes in human cultured monocytes in response to 4 chemokine challenges.

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