New PDF release: The Causes of Epilepsy: Common and Uncommon Causes in Adults

New PDF release: The Causes of Epilepsy: Common and Uncommon Causes in Adults

By Simon D. Shorvon, Frederick Andermann, Renzo Guerrini

Causation is a facet of epilepsy ignored within the clinical literature and within the conceptualization of epilepsy at a medical and experimental point. It used to be to therapy this deficiency that this ebook used to be conceived. The booklet opens with a draft etiological class that is going a way to filling the nosological void. The ebook is split into 4 etiological different types: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. each one bankruptcy considers subject matters in a constant type, facing the phenomenon of epilepsy in each one etiology, together with its epidemiology, medical beneficial properties and diagnosis, and any particular points of remedy. The e-book is a entire reference paintings, a listing of all vital explanations of epilepsy, and a medical software for all clinicians facing sufferers who've epilepsy. it's geared toward epileptologists and neurologists and gives a distillation of information in a kind that's priceless within the scientific environment.

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Additional info for The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children (Cambridge Medicine)

Sample text

R. Walshe (also neurologist to the National Hospital Queen Square and who was appointed editor of Epilepsia in 1959/60) could state: it is better to speak of “the epilepsies” according to the various known exciting factors than to keep the category of idiopathic epilepsy. Nevertheless, from the practical point of view of diagnosis and treatment the two categories of “idiopathic” and “symptomatic” epilepsy remain useful . . It has always been regarded as a heritable condition, though it obeys no known laws of inheritance, and it is probably that what is inherited – if anything be – is an instability of function in the cells of the cerebral cortex.

Further studies in this area might be well worth conducting, in the hope of uncovering common mechanisms (the Jacksonian meaning of “etiology”) that may give a clue to the genetic basis of epilepsy and these other conditions. Recent work on genetic copy-number variants is of great interest in this regard, and deletions or duplications might provide a mechanism for inheritance of comorbidities. Certainly, the current genetic inquiry into the causes of epilepsy has had only limited success, focusing as it has done on the artificially determined phenotypes, syndromes, and seizure classifications.

1973). William Lennox This brings this survey to 1960, and the publication by Lennox of his two-volume book – Epilepsy and Related Disorders (Lennox 1960) (Fig. 9). Lennox wrote extensively about the then current theories of etiology and his book is a good source of information on this topic. Lennox of course was a committed eugenicist and deeply interested in the genetic predisposition to seizures. His book provides a relatively clear explanation of his views on “causation” which can be summarized as follows: (1) Epilepsy is due to a combination of: (i) genetic (essential) causes; (ii) acquired causes; and (iii) precipitating causes.

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