The B7-CD28 Family Molecules (Molecular Biology Intelligence by Lieping Chen PDF

The B7-CD28 Family Molecules (Molecular Biology Intelligence by Lieping Chen PDF

By Lieping Chen

The B7-CD28 family members molecules are essentially the most intensively studied receptor-ligand structures within the box of immunology. this is often obtrusive from the explosive accumulation of literature, rather within the final ten years. contemporary years have witnessed quick discoveries and characterization of recent receptors and ligands within the relations. those new pathways, even though nonetheless of their infancy, have already introduced a lot pleasure to the sphere. even if, beforehand, there was no unmarried quantity to hide this whole sector. This publication used to be created to compile cutting-edge info and important pondering from the major investigators. This publication covers major territory of this quickly relocating box from structural biology and biochemical signalling to immunological capabilities and their strength purposes within the therapy of human illnesses. this is often a superb guide and reference for immunologists, health and wellbeing execs in addition to scientific scholars and graduate scholars in existence technological know-how box.

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Balamuth F, Leitenberg D, Unternaehrer J et al. Distinct Patterns of Membrane Microdomain Partitioning in Th1 and Th2 Cells. Immunity 2001; 15:729-738. 37. Michel F, Attal-Bonnefoy G, Mangino G. CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities. Immunity 2001; 15:935-945. 38. Mastar J, Hughes C. Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involve lipid raft aggregation. J Immunol 2001; 167:4378-4385. 39. Acuto O, Cantrell D. T cell activation and the cytoskeleton.

Kong Y-Y, Fischer K-D, Bachmann MF et al. Vav regulates peptide-specific apoptosis in thymocytes JEM 1998; 188:2099-2111. 97. Wu J, Motto DG, Koretzky GA et al. Vav and SLP-76interact and functionally cooperate in IL-2 gene activation. Immunity 1996; 4:593-602. 98. Bubeck WJ, Pappu R, Bu JY et al. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 1998; 9:607-616 99. Fischer KD, Zmuldzinas A, Gardner S et al. Defective T cell receptor signaling and positive selection of Vav-deficient CD4+ CD8+ thymocytes.

Duration of TCR stimulation determines costimulatory requirements of T cells. Immunity 1996; 5:41-52. 14. Teh HS, Teh SJ. High concentrations of antigenic ligand activate and no not tolerize naïve CD4 T cells in the absence of CD28/B7 costimulation. Cell Immunol 1997; 179:74-83. 15. Viola A, Schroeder S, Sakakibara Y et al. T lymphocyte costimulation mediated by reorganization of membrane microdimains. Science 1999; 283:680-682. 16. Herndon TM, Shan XC, Tsokos GC et al. ZAP-70 and SLP-76 regulate protein kinase θ and NF-κB activation in response to engagement of CD3 and CD28.

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