By Mauricio Rojas
During this state of the art exploration of a highly dynamic and fast-evolving box of analysis, top researchers proportion their collective knowledge at the position that stem cells may play within the context of physiological tension and lung damage. The textual content makes a speciality of reviewing the main relevant—and recent—ideas on utilizing neighborhood, endogenous, and exogenous progenitor/stem cells in fighting and treating damage to the lung. The lungs are the most complicated organs within the human physique, with a mature grownup lung boasting at the very least forty morphologically differentiated phone lineages. Our whole blood provide passes during the lung’s alveolar devices in the course of oxygenation. This interplay with the skin international, in addition to the intricacies of its constitution, makes the lung a hugely weak organ that's susceptible to quite a few sorts of damage and an infection. which means the mechanisms of lung fix are in themselves correspondingly complicated. as a result of their multipotentiality, in addition to the actual fact of the lung’s really fast mobilephone turnover, stem cells are regarded as a huge replacement cell-base treatment in lung harm. regardless of the debatable nature of stem telephone examine, there was growing to be curiosity in either neighborhood and endogenous stem cells within the lung. This hugely topical booklet with chapters on every little thing from utilizing mesenchymal stem cells in lung fix to the impression of actual job at the mobilization of stem and progenitor cells, represents a thrilling physique of labor via remarkable investigators and may be required interpreting for people with an curiosity within the topic.
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Extra info for Stem Cells in the Respiratory System
Am J Respir Cell Mol Biol 2007; 37(2): 152–159. 17. Hennrick KT, Keeton AG, Nanua S, Kijek TG, Goldsmith AM, Sajjan US, Bentley JK, Lama VN, Moore BB, Schumacher RE, Thannickal VJ, and Hershenson MB. Lung cells from neonates show a mesenchymal stem cell phenotype. Am J Respir Crit Care Med 2007; 175(11):1158–1164. 2 Mesenchymal Stem Cells for Lung Repair and Regeneration 35 18. Lama VN, Smith L, Badri L, Flint A, Andrei AC, Murray S, Wang Z, Liao H, Toews GB, Krebsbach PH, Peters-Golden M, Pinsky DJ, Martinez FJ, and Thannickal VJ.
7 Future Directions Consideration of the following questions is suggested as a basis for the design of future studies. First, what evidence supports or refutes identification of one or several types of lung stem cell? Second, what are the caveats to organization of lung progenitor cells as a classic stem cell hierarchy? Third, in the face of the large facultative progenitor cell pool, is a stem cell needed to maintain the lung epithelium? Fourth, could loss of the putative stem cell or alteration of stem cell function contribute to lung disease?
Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells. Stem Cells 2004; 22(7):1263–1278. 24. De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, and Hedrick MH. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 2003; 174(3):101–109. 25. Keyser KA, Beagles KE, and Kiem HP. Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation.