New PDF release: Photosensitizers in Medicine, Environment, and Security

New PDF release: Photosensitizers in Medicine, Environment, and Security

By Fabienne Dumoulin (auth.), Tebello Nyokong, Vefa Ahsen (eds.)

This e-book addresses the synthesis of photosensitizers, the most emphasis being at the new tools of synthesis equivalent to microwave, sonochemistry and using ionic beverages. It additionally addresses the photochemistry and photophysics of the photosensitizers by myself and together with nanoparticles, using the photosensitizers in environmental keep an eye on, protection and drugs. It discusses the typical buildings of the photosensitizers that are valuable to those purposes.

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Extra resources for Photosensitizers in Medicine, Environment, and Security

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Bioconjug Chem 13:249–263 95. Duan W, Smith K, Savoie H, Greenman J, Boyle RW (2005) Near IR emitting isothiocyanatosubstituted fluorophores: their synthesis and bioconjugation to monoclonal antibodies. Org Biomol Chem 3:2384–2386 96. Clarke OJ, Boyle RW (1999) Isothiocyanatoporphyrins, useful intermediates for the conjugation of porphyrins with biomolecules and solid supports. Chem Commun 2231–2232 97. Bakleh ME, Sol V, Estieu-Gionnet K, Granet R, Déléris G, Krausz P (2009) An efficient route to VEGF-like peptide porphyrin conjugates via microwaveassisted ‘click-chemistry’.

Berthold HJ, Franke S, Thiem J, Schotten T (2010) Ex post glycoconjugation of phthalocyanines. J Org Chem 75:3859–3862 137. Alvarez-Mico X, Calvete MJF, Hanack M, Ziegler T (2007) Expeditious synthesis of glycosylated phthalocyanines. Synthesis 14:2186–2192 138. Hirohara S, Obata M, Saito A, S-i O, Ohtsuki C, Higashida S, S-i O, Okura I, Sugai Y, Mikata Y, Tanihara M, Yano S (2004) Cellular uptake and photocytotoxicity of glycoconjugated porphyrins in HeLa cells. Photochem Photobiol 80:301–308 1 Design and Conception of Photosensitisers 43 139.

Then at an intracellular level, uptake into specific organelle is likely to improve the efficacy of the treatment. 1 Design and Conception of Photosensitisers 21 Targeting of the High Metabolism of Tumour Folic acid (77), as a vitamin (B9), is highly demanded by prolifering cells. This is the reason why cancer cells generally overexpress folate receptors [99]. Photosensitiser covalently binded to folic acid is therefore a potentially efficient cancer targeting conjugate. The folate-porphyrin conjugate 79 was designed for this purpose [100, 101], with a short spacer.

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