New Frontiers of Network Analysis in Systems Biology by Fumio Arai, Kentaro Hosokawa (auth.), Avi Ma'ayan, Ben D. PDF

New Frontiers of Network Analysis in Systems Biology by Fumio Arai, Kentaro Hosokawa (auth.), Avi Ma'ayan, Ben D. PDF

By Fumio Arai, Kentaro Hosokawa (auth.), Avi Ma'ayan, Ben D. MacArthur (eds.)

The quickly constructing box of structures biology is influencing many points of organic study and is predicted to rework biomedicine. a few rising offshoots and really good branches in structures biology are receiving specific recognition and have gotten hugely lively parts of study. This choice of invited studies describes the various most modern state-of-the-art experimental and computational advances in those rising sub-fields of platforms biology. specifically, this assortment makes a speciality of the learn of mammalian embryonic stem cells; new applied sciences regarding mass-spectrometry proteomics; unmarried phone measurements; tools for modeling advanced stochastic platforms; network-based class algorithms; and the progressive rising box of platforms pharmacology.

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Becskei A, Se´raphin B, Serrano L (2001) Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J 20(10):2528–2535 4. Bolouri H, Davidson E (2002) Modeling transcriptional regulatory networks. BioEssays 24(12):1118–1129 5. Boyer L, Lee T, Cole M, Johnstone S, Levine S, Zucker J, Guenther M, Kumar R, Murray H, Jenner R, et al (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122(6):947–956 6. Chang HH, Hemberg M, Barahona M, Ingber DE, Huang S (2008) Transcriptome-wide noise controls lineage choice in mammalian progenitor cells.

In many cases these distributions are bimodal (or even multimodal) suggesting the existence of multiple expression phenotypes in isogenic populations. This was first demonstrated in the pre-fluorescence technology era by Novick and Weiner [34] using inducer dilution experiments and more recently tracked in single cells experimentally using the Lac operon system [1, 38]. It has also been shown [3] that unicellular organisms can switch between these multiple phenotypic states which, depending on the time scale of environmental fluctuations, can enhance their chances for survival, a property linked to antibiotic resistance.

The system exhibits bistability for 0 < g2 < 0. 25 For simplicity let’s explore the case m ¼ 2. Fixed-points are solutions of a cubic equation, and, in general, there are three distinct solutions. 1 shows how the production and decay terms intersect (and thus the positions of the fixed-points change) as g is varied. 5) denoted B and C Fig. 1. As g increases, B and C approach each other and eventually coalesce at the point D ( ¼ 0. 5), when g2 ¼ 0. 25 and the production and decay rates intersect tangentially.

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