By Jorge A Lazareff
Neural Tube Defects are a gaggle of comparable yet person pathologies which are the commonest congenital anomalies of the critical apprehensive approach.
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Neural Tube Defects are a gaggle of similar yet person pathologies which are the most typical congenital anomalies of the primary fearful procedure. the significance of this situation has generated a wide physique of literature that seldom was once written for the clinician in a complete and didactic demeanour.
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Additional info for Neural Tube Defects
Thus its presence in the amniotic fluid is diagnostic of neural tube defect. Again, amniocentesis is undertaken only if karyotyping is necessary. Role of ultrasound in antenatal diagnosis of myelomeningocele Traditional 2D ultrasound has replaced the maternal AFP measurement. While performing fetal ultrasound, gestational age has to be correlated with the ultrasound findings. There are two types of ultrasound examination offered to a pregnant lady as part of antenatal care. Screening ultrasound is undertaken in the second trimester by an obstetrician.
September 20, 2010 16:4 spi-b864 9in x 6in Myelomeningocele b864-ch04 49 6. Various central canal anomalies such as slit-like central canal. 7. Massive necrosis throughout the plaque region. Histology of placode 1. Elongation of neural structures in the axial plane with a relative decrease in dorsal elements. 2. Paucity of number of neurons. 3. Presence of multiple areas of vacuolization and gliosis indicative of neural insult or injury. Histochemistry of placode 1. GFAP (glial cell marker) positivity throughout the placode except in areas of vacuolization.
The fetus must have a normal karyotype, with absence of other congenital malformations. 3. Evidence of Chiari type II malformation present. 4. Absence of severe hydrocephalus (maximum lateral ventricular diameter <17 mm). 5. Normal leg movement in utero with absence of talipes foot or club foot deformity. 6. Lesion higher than sacral level 1. September 20, 2010 16:4 spi-b864 Myelomeningocele 9in x 6in b864-ch04 35 The data collected in patients born after intrauterine repair of the MMCL defect was observed to have better preservation of movements of the lower extremities.