Harvard Business Review (June 2016) - download pdf or read online

Harvard Business Review (June 2016) - download pdf or read online

Review: Harvard company evaluation is the journal for decision-makers. It's the place worldwide company leaders flip for concepts and concept. With state-of-the-art articles from specialists, Harvard enterprise overview is an unequalled resource for management and administration instruments and strategies which are severe to good fortune and survival in today's enterprise enviornment round the world.

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Two related isoforms have also been identified in human kidney. The conductances of ClC-2 and ClC-K channels have not been published. Expression of ClC-K2L and CLC-K2s in Xenopus laevis oocytes yielded outwardly rectifying anion currents which were blocked by DIDS and DPC. An important feature of CIC-K1 is its increased transcription in dehydrated animals, indicating a possible function for the CIC-K1 group of channels in volume regulation. A third channel type, ClC-3, is found in kidney and other organs, but is less than 30% identical to other ClC proteins.

The amino acid sequence of 5GLTl is highly conserved in mammals. e. promote intracellular accumulation of nutrients, vitamins, bile salts and anions. The energy for uphill transport of these solutes is provided by the Na+ electrochemical gradient across the cell membrane, generated by the operation of the Na+,K+ pump. This is referred to as the sodium-gradient hypothesis. (c) Na+/H+ exchanger Recent review articles Reithmeier (1994); Pouyssegur (1994). Overview The Na+ /H+ exchanger (NHE) is a carrier that exchanges a Na+ for a H+ (in an electroneutral fashion).

G. g. basolateral Na+,K+,2CI- cotransporter, a K+ channel and Na+,K+-ATPase in Cl--secreting epithelia). Carriers and channels in epithelial cells dissipate the ion gradients generated by ion pumps. Thus, carriers and channels can be thought of as 'leak' pathways in parallel or in series with a pump. 1. 1 Sodium coupled systems In epithelia such as those of small intestine, renal proximal tubule and gallbladder, Na+ entry across the apical membrane is carrier-mediated. We will consider four kinds of transporters that contribute to Na+ entry: the Na+-glucose cotransporter, the Na+ /H+ exchanger, the NaK2CI cotransporter and the thiazide-sensitive NaCl cotransporter.

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