By Maureen A. O’Malley (auth.), Orkun S. Soyer (eds.)
The ebook goals to introduce the reader to the rising box of Evolutionary platforms Biology, which ways classical structures biology questions inside an evolutionary framework. An evolutionary technique may well permit figuring out the importance of saw range, discover “evolutionary layout ideas” and expand predictions made in version organisms to others. furthermore, evolutionary structures biology can generate new insights into the adaptive panorama through combining molecular platforms biology versions and evolutionary simulations. This perception can let the improvement of extra precise mechanistic evolutionary hypotheses.
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Extra info for Evolutionary Systems Biology
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The reason becomes clear if one considers that most amino acid substitutions will reduce rather than increase an enzyme’s activity, and thus reduce the metabolic flux that the enzyme can support. The observation that fewer amino acid changes can be tolerated in enzymes with high flux means that reduced flux in such enzymes is more likely to have adverse consequences for the organism, and that such enzymes are thus likely to be eliminated via natural selection. In other words, the biological function of a metabolic network constrains the evolution of its parts by point mutations.