By Frank J. Dixon, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr (Eds.)
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Extra resources for Advances in Immunology, Vol. 40
Moreover, Miki and co-workers (1982) showed that the signal(s) provided by a T cell-replacing factor to synchronized human B lymphoblastoid cells could be transduced only when cells were in the G1 phase. , 1986). , 1978). , 1983; Hoffmann, 1980b). , 1982). It has been suggested that the primary role of IL-1 is the promotion of activation but, alone, it supports neither growth nor differentiation. This latter notion has recently been challenged by Pike and Nossal (1985), who suggested that IL-1 alone can promote both growth and differentiation of single, isolated, hapten-specific B cells.
8, lymphokines with reported differentiative effects are primarily thought to act after the proliferative phase. Much less investigation into the temporal requirements of various lymphokines has been carried out in the human system. Studies in the human system that have examined this issue have shown that the presence of T cell factors during initial activation of peripheral blood B cells with SA did not result in an increase in the total number of activated cells but did result in the delivery of a predivisional differentiative signal to some of the B cells that resulted in significant enhancement in the subsequent generation of Ig-secreting cells upon culture with T cell-derived lymphokines (Jelinek and Lipsky, 1985).
Proposed model of the role of the various lymphokines in human B cell activation. (Jelinek and Lipsky, unpublished observations). It remains possible, therefore, that the high-molecular-weight form of BCGF (BCGF-11) is the functionally active lymphokine in this regard. The early requirement for T cell influences to promote maximal IL%driven B cell responses could have many explanations. Although T cell influences are not required for the expression of IL-2 receptors, they may be necessary for B cells to express high-avidity IL-2 receptors.