By David M. Panchision (auth.), Donald G. Phinney (eds.)
This is complete review of an essential zone of medical enquiry, which covers a extensive spectrum of concerns. With contributions from a few of the key researchers within the box, grownup Stem Cells: Biology and techniques of study deals readers a old viewpoint in addition to special insights into state-of-the-art suggestions. the quantity contextualizes the new discovery of stem/progenitor cellphone populations resident in lots of grownup tissues and organs. It confronts the complexities scientists face in attempting to validate those cells, whereas it additionally describes and seriously evaluates the tools presently used to evaluate stem phone self-renewal. The chapters additionally search to tell apart this procedure from different features of mobile survival, reminiscent of the rules of lifestyles span, senescence, and immortalization at a molecular point.
The monograph starts off with a piece that study the fundamental biology of grownup stem cells, together with chapters at the rising position of microRNAs in regulating their destiny and the molecular mechanisms that govern their self-renewal, the ebook strikes directly to research the various methodologies hired in characterizing those elusive parts of our genetic makeup. the second one part info in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem phone paradigm, and considers the functionality of ABC transporters and aldehyde dehydrogenase in grownup stem-cell biology. the ultimate part shifts the focal point to the life-span rules and immortalization and contours a bankruptcy at the melanoma stem telephone paradigm.
This is an authoritative quantity on one of many frontiers of genetic learn, and may function a priceless source, not only for proven scientists but in addition for these now getting into the sector of stem telephone biology.
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Additional resources for Adult Stem Cells: Biology and Methods of Analysis
Carpenter MK, Inokuma MS, Denham J et al (2001) Enrichment of neurons and neural precursors from human embryonic stem cells. Exp Neurol 172:383–397. Chambers I, Tomlinson SR (2009) The transcriptional foundation of pluripotency. Development 136:2311–2322. Chen HL, Panchision DM (2007) Concise review: bone morphogenetic protein pleiotropism in neural stem cells and their derivatives – alternative pathways, convergent signals. Stem Cells 25:63–68. Chen HL, Pistollato F, Hoeppner DJ et al (2007) Oxygen tension regulates survival and fate of mouse CNS precursors at multiple levels.
2009). The maintenance of quiescent HSCs is the main role of the HSC niche in bone marrow (BM). Cytokines, growth factors, local environmental factors, and adhesion molecules that anchor HSCs to the endosteum play a key role in maintaining quiescence. The concept of coexistence of different types of HSCs in niches – quiescent and cycling stem cells – is now accepted and proved for other types of stem cells. For example, the Clevers group demonstrated that the leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-positive cells in the pyloric gland are actively cycling pyloric stem cells, whereas villin+ stem cells are quiescent (Qiao et al.
Analysis of CDK2 deficient mice showed that CDK2 is required for overall proliferation and self-renewal 1 Molecular Mechanisms Regulating Adult Stem Cell Self-Renewal FoxO3 23 Shh ? IP SC Renewal genes Notch ? HIF1α Shh Wnt3 CDK Pax6 DII Sox2 Foxg1 ? CDK-i Bmi1 p53 Smad Arf HIF1α Myc BMP EGF, FGF2 Astr Wnt3 ? NB Fig. 7 Molecular control of self-renewal versus quiescence. Schematic diagram illustrating factors controlling cell cycle progression or expression of genes promoting self-renewal, multipotency, and/or repression of lineage commitment.